Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis

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Karl Wooldridge
Horizon Scientific Press, 2009 - 511 pages
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Secreted proteins are particularly important in bacterial pathogenesis. These proteins have a range of biological functions from host cell toxicity to more subtle alterations of the host cell for the benefit of the invader. The importance of protein secretion to bacterial pathogens is exemplified by the array of mechanisms that have evolved for this purpose. This extensive publication - on bacterial secreted proteins, the secretory systems of bacteria, and the vital role of secreted proteins in bacterial pathogenesis - will be of immense value to all microbiologists, molecular biologists, public health scientists, and researchers engaged in the study of pathogenesis, drug design, and vaccine development. A skillful selection of topics and a panel of acknowledged experts have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems, including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, the specialized mechanisms for secretion across the Gram-negative outer membrane, the systems for transport across both membranes of Gram-negative bacteria, the protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili, and the less well-defined pathways. Section two describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary, and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each of the book's chapters can be read in isolation. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. It is a recommended reference volume for all microbiology libraries.

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The Sec Protein Secretion System
The Twinarginine Translocation Pathway
Type I Bacterial Secretion Systems
Type II Secretory System T2SS in Gramnegative Bacteria a Molecular Nanomachine for Secretion of Sec and Tatdependent Extracellular Proteins
The Type III Secretion System
Mechanistic and Structural Analysis of Type IV Secretion Systems
Type V Secretion
Assembly and Secretion of Surface Fibres in GramNegative Bacteria
Protein Secretion and the Pathogenesis of Campylobacter jejuni
Listeria monocytogenes
Protein Secretion and Pathogenesis in Neisseria meningitidis
The Role of Secreted Proteins in the Pathogenesis of Helicobacter pylori infection
Protein Secretion in Legionella pneumophila
Bordetella pertussis
Secreted Proteins of Vibrio cholerae
The Secreted Proteins of Pseudomonas aeruginosa Their Export Machineries and How They Contribute to Pathogenesis

Secretome Mapping in Grampositive Pathogens
Nonclassical Secretion
Secreted Proteins and Virulence in Salmonella enterica
Secreted and Exported Proteins Important to Mycobacterium tuberculosis Pathogenesis
Secretion systems of the enterobacterial phytopathogen Erwinia

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