Retrotransposition, Diversity and the BrainFred H. Gage Springer Science & Business Media, 2007 M11 16 - 123 páginas The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learned from the discovery of the mechanism for diversityinthe immune system maybe usefultothe investigation ofthe mechanism of diversity in neurons. |
Dentro del libro
Resultados 1-5 de 19
Página 2
... addition to its RT domain, and in having a conserved core structure of the telomerase RNA moiety (Fig. 2B). Two different types of models have been considered for the evolution of telomerase. These models, described next, are not ...
... addition to its RT domain, and in having a conserved core structure of the telomerase RNA moiety (Fig. 2B). Two different types of models have been considered for the evolution of telomerase. These models, described next, are not ...
Página 3
... addition, the telomeric DNA bases, even those that do not base-pair with the template, interact with the TERT moiety of telomerase, and such interaction can have a large effect on the catalytic reaction rate itself. This effect occurs ...
... addition, the telomeric DNA bases, even those that do not base-pair with the template, interact with the TERT moiety of telomerase, and such interaction can have a large effect on the catalytic reaction rate itself. This effect occurs ...
Página 4
... addition to its clear function as a template. In summary, such results suggest that interactions involving the telomerase RNA within the telomerase RNP can greatly influence the course of its polymerization and intrinsic hydrolysis ...
... addition to its clear function as a template. In summary, such results suggest that interactions involving the telomerase RNA within the telomerase RNP can greatly influence the course of its polymerization and intrinsic hydrolysis ...
Página 5
... addition, various post-transcriptional control mechanisms resulting in regulation of telomerase activity have been described for certain mammalian cells. However, much research remains to be done to understand fully the control of ...
... addition, various post-transcriptional control mechanisms resulting in regulation of telomerase activity have been described for certain mammalian cells. However, much research remains to be done to understand fully the control of ...
Página 24
Alcanzaste el límite de visualización de este libro.
Alcanzaste el límite de visualización de este libro.
Contenido
1 | |
Molecular and Circuit Mechanisms for Hippocampal Learning | 13 |
Boeke W An L Dai E S Davis J S Han K A ODonnell L Z Scheifele | 40 |
Generation of Diversity | 53 |
Endogenous Retroviruses and Human Neuropsychiatric Disorders | 65 |
Is Psychosis Due to RetroviralRetrotransposon Integration Close | 87 |
Microcephalies and DNA Repair | 109 |
Subject Index | 121 |
Otras ediciones - Ver todas
Términos y frases comunes
Acad Sci USA alleles amino acid antibodies APOBEC3G associated asymmetry bipolar disorder Blackburn EH Boeke JD brain cell cycle cellular cerebral Chen chromosome complex cortex cortical Crow TJ cues differentiation disease disorder DNA repair double-stranded encoding endogenous retroviruses eukaryotic evolution exons factors function Gage genetic HERV-W hippocampal hominin homologous hot L1s human genome human L1 hypothesis infection insertions intron L1 activity L1 elements L1 retrotransposons mammalian mice microcephaly Moran JV Muotri mutations Natl Acad Sci neural neurogenesis neuronal Neurosci NMDA receptors Nucleic Acids onset ORF1 Ostertag pathway phenotype polymorphisms population Proc Natl Acad promoter protein Psychiat psychosis pyramidal cells regions replication retroelements retrotransposition retroviral reverse transcriptase risk of schizophrenia RNA chaperones RNA world role schizophrenia sequence somatic Sox2 specific stem cells structure studies syncytin syndrome target telomerase activity telomerase RNA telomere telomere length tissues Torrey transcription transposon virus Y chromosome yeast Yolken RH
Pasajes populares
Página 50 - C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW,...
Página 117 - Hakem, R., Hakem, A., Duncan, GS, Henderson JT, Woo, M., Soengas, MS, Elia A., de la Pompa, JL, Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, SA, Lowe, SW, Penninger, JM, and Mak, TW (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo.
Página 30 - McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J...
Página 31 - Furey, TS, Galagan, J., Gilbert, JG, Harmon, C., Hayashizaki, Y., Haussler, D., Hermjakob, H., Hokamp, K., Jang, W., Johnson, LS, Jones, TA, Kasif, S., Kaspryzk, A., Kennedy, S., Kent, WJ, Kitts, P., Koonin, EV, Korf, I., Kulp, D., Lancet, D., Lowe, TM, McLysaght, A., Mikkelsen, T., Moran, JV, Mulder, N., Pollara, VJ, Ponting, CP, Schuler, G., Schultz, J., Slater, G., Smit, AF, Stupka, E., Szustakowski, J., Thierry-Mieg, D., Thierry-Mieg, J., Wagner, L., Wallis, J., Wheeler, R., Williams, A., Wolf,...
Página 10 - Feng, J., Funk. WD, Wang, SS., Weinrich. SL, Avilion, AA, Chiu, CP., Adams, RR, Chang, E., Allsopp. RC, Yu. J., Le. S., West, MD, Harley. CB, Andrews. WH, Greider. CW, and Villeponteau, B.
Página 51 - Davis, RW, Federspiel, NA, Abola, AP, Proctor, MJ, Myers, RM, Schmutz, J., Dickson, M., Grimwood, J., Cox, DR, Olson, MV, Kaul, R., Raymond, C., Shimizu, N., Kawasaki, K., Minoshima, S., Evans, GA, Athanasiou, M., Schultz, R., Roe, BA, Chen, F., Pan, H., Ramser, J., Lehrach, H., Reinhardt, R., McCombie, W. R., de la Bastide, M., Dedhia, N., Blocker, H., Hornischer, K., Nordsiek, G., Agarwala, R., Aravind, L., Bailey, JA, Bateman, A., Batzoglou, S., Birney, E., Bork, P., Brown, DG, Burge, CB, Cerutti,...
Página 119 - Y (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Página 119 - O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti...
Página 84 - Perron H, Garson JA, Bedin F, Beseme F, Paranhos-Baccala G, Komurian-Pradel F, Mallet F, Tuke PW, Voisset C, Blond JL, Lalande B, Seigneurin JM, Mandrand B (1997) Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis.