Sequence — Evolution — Function: Computational Approaches in Comparative GenomicsSpringer Science & Business Media, 2013 M06 29 - 462 páginas Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Key topics covered in this textbook are: |
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... acid residues each that have , say , 80 % identical residues , we can calculate the probability of this occurring by ... amino acid residue is conserved in all the sequences , they align unequivocally and are indisputable homologs . - A ...
... amino acid residues are shown in bold and / or shaded . The following proteins are listed : A. aeolicus , aq_075 ; B. subtilis , RpmJ ; C. jejuni , Cj1591 ; C. trachomatis , CT786 ; E. coli , RpmJ ; H. pylori , HP1297 ; L. lactis ...
... amino acid residues required for functioning in the stomach have evolved independently ( convergently ) in different lineages of lysozymes . Importantly , however , this set of convergent positions consists of only seven amino acid residues ...
... amino acid residues in the active centers are likely to exist , and these are precisely the kind of similarity that is expected to emerge due to functional convergence . These similarities , however , do not translate into structural ...
... amino acid residues in their active sites and have similar catalytic mechanisms . These shared features support the notion that , despite low sequence similarity , such proteins are homologous . Consider , for example , the structure of ...
Contenido
3 | |
25 | |
Information Sources for Genomics 51 | 50 |
Principles and Methods of Sequence Analysis | 111 |
Genome Annotation and Analysis | 193 |
Comparative Genomics and New Evolutionary | 227 |
Genomes and the Protein Universe | 357 |
Peering through the crystal ball 371 | 370 |
Appendices | 381 |
References | 403 |
Index | 457 |
Otras ediciones - Ver todas
Sequence — Evolution — Function: Computational Approaches in Comparative ... Eugene Koonin,Michael Y. Galperin Vista previa limitada - 2002 |
Sequence — Evolution — Function: Computational Approaches in Comparative ... Eugene Koonin,Michael Y. Galperin Sin vista previa disponible - 2010 |
Sequence — Evolution — Function: Computational Approaches in Comparative ... Eugene Koonin,Michael Y. Galperin Sin vista previa disponible - 2013 |