Mood Genes: Hunting for Origins of Mania and DepressionOxford University Press, 1999 - 237 páginas We know that the likelihood of developing many physical diseases, such as diabetes, is determined by genes. But can abnormalities in specific genes also play a part in the development of mental disorders? And, if so, can these genes actually be identified and their discovery put to use in prevention and treatment? In Mood Genes, leading psychiatrist and biological researcher Samuel Barondes answers these questions in a way that renders a complex subject both exciting and understandable. Focusing on manic depressive illness, which affects about one percent of the population and has long been known to run in families, Barondes describes the fascinating hunt for genes--called mood genes--that influence the inherited vulnerability to severe mood disorders. He builds the compelling story of this hunt on the histories of two families riddled with manic-depression, explaining what it means to have an inherited predisposition to a severe mood disorder, how to find the mood genes that are responsible, and what will happen as mood genes are found. Not long ago, saying that a behavioral tendency was genetic was generally taken to mean that it was unchangeable. Now we know that finding genes that influence particular behavioral variations may not just be used to foretell our destinies--but also to forestall them. |
Contenido
Prologue | 1 |
A Single Morbid Process? | 25 |
The Astonishing Leap from Traits to Genes | 49 |
From Peas to People | 63 |
Some Tools for the Hunt | 85 |
Hunting Without a Map | 113 |
Anas Family | 131 |
Hot Spots in the Genome | 145 |
Both Good Seed and Bad | 165 |
Grappling with Fate | 177 |
Some Trouble with Michael | 189 |
Notes | 195 |
Bibliography | 212 |
Acknowledgments | 227 |
229 | |
Otras ediciones - Ver todas
Mood Genes: Hunting for Origins of Mania and Depression Samuel H. Barondes Sin vista previa disponible - 1998 |
Mood Genes: Hunting for Origins of Mania and Depression Samuel H. Barondes Sin vista previa disponible - 1998 |
Términos y frases comunes
abnormal Alzheimer's disease Amish Ana's family APOE Archibald Garrod Barondes basis bb Bb bb behavior biological bipolar disorder brain called centimorgan chemical chromosome 18 clinical color controlled Costa Rica David depressive illness diagnosis DNA samples dominant allele drugs Egeland encodes enzyme evidence example Flora flowers Freimer Freud G6PD Galton Garrod genetic map geneticists genome genotype hemoglobin hereditary heredity Housman human genetic hunt for mood Huntington's disease inherited Jerry Kraepelin lithium loci locus lod score major depression males mania manic episode manic-depressive illness markers Mendel Mendelian mental illness Michael molecular mood disorder mood genes mood-gene alleles mutations Nature Genet Nelson normal offspring pairs parents patients pattern peas pedigree percent phenotype polymorphisms porphyria protein relatives Rican riflip risk role sex cells sickle cell allele sickle cell anemia single gene specific Sturtevant susceptibility genes symptoms testing tion twins urine variations vulnerability X chromosome