Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página v
... Aging and Longevity 3 Leonid A. Gavrilov and Natalia S. Gavrilova I. Introduction 3 II. General Overview of the Reliability Theory Approach 5 III. Mortality, Failure, and Aging ... Mechanisms of DR 70 V. Small-Molecule CR Mimetics 82 v ...
... Aging and Longevity 3 Leonid A. Gavrilov and Natalia S. Gavrilova I. Introduction 3 II. General Overview of the Reliability Theory Approach 5 III. Mortality, Failure, and Aging ... Mechanisms of DR 70 V. Small-Molecule CR Mimetics 82 v ...
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Edward J. Masoro, Steven N. Austad. IV. Mechanisms of DR 70 V. Small-Molecule CR Mimetics 82 VI. Conclusions 89 References 90 4. Hematopoietic Stem Cells, Aging, and Cancer 105 Deborah R. Bell and Gary Van Zant I. Stem Cells 105 II. Stem ...
Edward J. Masoro, Steven N. Austad. IV. Mechanisms of DR 70 V. Small-Molecule CR Mimetics 82 VI. Conclusions 89 References 90 4. Hematopoietic Stem Cells, Aging, and Cancer 105 Deborah R. Bell and Gary Van Zant I. Stem Cells 105 II. Stem ...
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... aging are not mutually exclusive, and both evolutionary mechanisms may operate at the same time. The main difference between the two theories is that in the mutation accumulation theory, genes with negative effects at old age accumulate ...
... aging are not mutually exclusive, and both evolutionary mechanisms may operate at the same time. The main difference between the two theories is that in the mutation accumulation theory, genes with negative effects at old age accumulate ...
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... aging and failure (which will be discussed later), despite the obvious differences in specific underlying mechanisms of aging. B. Mortality Laws in the Biology of Life Span Attempts to develop a fundamental quantitative theory of aging ...
... aging and failure (which will be discussed later), despite the obvious differences in specific underlying mechanisms of aging. B. Mortality Laws in the Biology of Life Span Attempts to develop a fundamental quantitative theory of aging ...
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... ageing C. elegans. Nature, 419, 808–814. Hirsch, A. G., Williams, R. J., & Mehl, P. (1994). Kinetics of medfly mortality ... Mechanisms of Ageing and Development, 27,43–62. Hjalmarsson, O., Hagberg, B., Hagberg, G., Kubli, F., Patel, N ...
... ageing C. elegans. Nature, 419, 808–814. Hirsch, A. G., Williams, R. J., & Mehl, P. (1994). Kinetics of medfly mortality ... Mechanisms of Ageing and Development, 27,43–62. Hjalmarsson, O., Hagberg, B., Hagberg, G., Kubli, F., Patel, N ...
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Academy of Sciences activity adult age-associated age-related age-specific alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology extend life span female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature neurons organisms overexpression oxidative stress pathway percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast