Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página vi
... Sir2, and p53 Signaling 154 IV. Mouse Models of Aging 155 V. Mouse Models of Accelerated Aging 158 VI. Mouse Models of Delayed Aging 161 VII. Links to p53 in Mouse Aging Models 162 VIII. Mutant Mouse p53 Models, Aging, and Cancer 164 IX ...
... Sir2, and p53 Signaling 154 IV. Mouse Models of Aging 155 V. Mouse Models of Accelerated Aging 158 VI. Mouse Models of Delayed Aging 161 VII. Links to p53 in Mouse Aging Models 162 VIII. Mutant Mouse p53 Models, Aging, and Cancer 164 IX ...
Página 72
... Sir2 longevity regulator is activated by reduced metabolic rate, which might free up NAD, a co-substrate of the enzyme. Clearly, claims that increased longevity is caused by reduced metabolic rate should be avoided, no matter how ...
... Sir2 longevity regulator is activated by reduced metabolic rate, which might free up NAD, a co-substrate of the enzyme. Clearly, claims that increased longevity is caused by reduced metabolic rate should be avoided, no matter how ...
Página 76
... Sir2 longevity gene in yeast and worms) were shown to be elevated in DR rats, which attenuates cells' susceptibility to apoptosis by sequestering the pro-apoptotic protein Bax away from mitochondria (Cohen et al., 2004b). SIRT1 also ...
... Sir2 longevity gene in yeast and worms) were shown to be elevated in DR rats, which attenuates cells' susceptibility to apoptosis by sequestering the pro-apoptotic protein Bax away from mitochondria (Cohen et al., 2004b). SIRT1 also ...
Página 80
... Sir2 enzyme is a nicotinamide (NAM)-sensitive enzyme that extends yeast life span by deacetylating histones and stabilizing repetitive DNA. PNC1 encodes an enzyme that depletes nicotinamide and activates Sir2. PNC1 can be viewed as a ...
... Sir2 enzyme is a nicotinamide (NAM)-sensitive enzyme that extends yeast life span by deacetylating histones and stabilizing repetitive DNA. PNC1 encodes an enzyme that depletes nicotinamide and activates Sir2. PNC1 can be viewed as a ...
Página 81
... Sir2 enzymatic activity in higher organisms is not known. Interestingly, the SIR2 gene is conserved in higher eukaryotes, and its ability to extend life span is conserved at least up to worms and flies (Helfand, 2004; Tissenbaum ...
... Sir2 enzymatic activity in higher organisms is not known. Interestingly, the SIR2 gene is conserved in higher eukaryotes, and its ability to extend life span is conserved at least up to worms and flies (Helfand, 2004; Tissenbaum ...
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Academy of Sciences activity adult age-associated age-related age-specific alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology extend life span female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature neurons organisms overexpression oxidative stress pathway percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast