Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página 18
... ( Tatar et al . , 1993 ) . Interestingly , the failure kinetics of where B and M are universal species- specific invariants . Sometimes this relationship is also called the Strehler - Mildvan correlation ( Strehler , 1978 ; Strehler ...
... ( Tatar et al . , 1993 ) . Interestingly , the failure kinetics of where B and M are universal species- specific invariants . Sometimes this relationship is also called the Strehler - Mildvan correlation ( Strehler , 1978 ; Strehler ...
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... Tatar, M. (2002). The aging baboon: comparative demography in a non-human primate. Proceedings of the National Academy of Sciences of the USA, 99, 9591–9595. Brooks, A., Lithgow, G. J., & Johnson, T. E. (1994). Mortality rates in a ...
... Tatar, M. (2002). The aging baboon: comparative demography in a non-human primate. Proceedings of the National Academy of Sciences of the USA, 99, 9591–9595. Brooks, A., Lithgow, G. J., & Johnson, T. E. (1994). Mortality rates in a ...
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... Tatar, 2001). C. Diet Composition Several laboratories have been instrumen- tal in addressing the question of whether the DR effect is due to the total reduction in food intake or the lack of a specific component. Early on, reduced ...
... Tatar, 2001). C. Diet Composition Several laboratories have been instrumen- tal in addressing the question of whether the DR effect is due to the total reduction in food intake or the lack of a specific component. Early on, reduced ...
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... ( Tatar et al . , 2003 ) . In mice , three transgenic " knocking outs " of endocrine genes have been shown to extend life span , namely the growth hormone ( GH ) receptor , the insulin receptor ( specifically in fat cells ) , or a ...
... ( Tatar et al . , 2003 ) . In mice , three transgenic " knocking outs " of endocrine genes have been shown to extend life span , namely the growth hormone ( GH ) receptor , the insulin receptor ( specifically in fat cells ) , or a ...
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... ( Tatar et al . , 2003 ) . These observations strongly argue that DR does not simply change metabolism or ROS output , as was pre- viously thought , but rather it induces a defense program that provides resistance to a wide array of ...
... ( Tatar et al . , 2003 ) . These observations strongly argue that DR does not simply change metabolism or ROS output , as was pre- viously thought , but rather it induces a defense program that provides resistance to a wide array of ...
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Academy of Sciences activity adult age-associated age-related age-specific aging process alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature nematodes neurons organisms overexpression oxidative stress percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast