Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página 52
... activity is also charac- teristic of aging . Compared to young adults , elderly humans were found to exhibit a two- to four - fold increase in plasma levels of inflammatory media- tors such as cytokines ( e.g. , tumor necrosis factor ...
... activity is also charac- teristic of aging . Compared to young adults , elderly humans were found to exhibit a two- to four - fold increase in plasma levels of inflammatory media- tors such as cytokines ( e.g. , tumor necrosis factor ...
Página 54
... activity in the mutant mice of Tyner and colleagues may cause aging by inappropriately enhancing apoptosis , an action that simultane- ously protects against the occurrence of cancer . Several other studies intimately link cancer and ...
... activity in the mutant mice of Tyner and colleagues may cause aging by inappropriately enhancing apoptosis , an action that simultane- ously protects against the occurrence of cancer . Several other studies intimately link cancer and ...
Página 71
... activities such as growth and reproduc- tion ( Charlesworth , 2000 ; Kirkwood & Holliday , 1979 ; Medawar , 1946 ) ... activity and life span ( Speakman et al . , 2003 , 2004 ) . With regards metabolic theories of DR , this finding is ...
... activities such as growth and reproduc- tion ( Charlesworth , 2000 ; Kirkwood & Holliday , 1979 ; Medawar , 1946 ) ... activity and life span ( Speakman et al . , 2003 , 2004 ) . With regards metabolic theories of DR , this finding is ...
Página 74
... activity of catalase and lower lipid peroxidation than AL con- trols ( Koizumi et al . , 1987 ; Mote et al . , 1991 ) , although lower levels of mRNA of other defense genes such as CuZn- superoxide dismutase ( SOD ) , glutathione ...
... activity of catalase and lower lipid peroxidation than AL con- trols ( Koizumi et al . , 1987 ; Mote et al . , 1991 ) , although lower levels of mRNA of other defense genes such as CuZn- superoxide dismutase ( SOD ) , glutathione ...
Página 75
... activity , making direct comparisons between studies difficult . That aside , perhaps the most convincing evidence against the free - radical theory of aging is that mice with an SOD2 defi- ciency , which have increased oxidative damage ...
... activity , making direct comparisons between studies difficult . That aside , perhaps the most convincing evidence against the free - radical theory of aging is that mice with an SOD2 defi- ciency , which have increased oxidative damage ...
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Academy of Sciences activity adult age-associated age-related age-specific aging process alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature nematodes neurons organisms overexpression oxidative stress percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast