Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página v
... Age-Associated Diseases 45 IV. Primary Aging, Secondary Aging, and “Normal Aging” 46 V. Evolutionary Theory and Age-Associated Diseases 49 VI. Analysis of Two Major Age-Associated Disease Processes 50 VII. Summary and Conclusions 55 ...
... Age-Associated Diseases 45 IV. Primary Aging, Secondary Aging, and “Normal Aging” 46 V. Evolutionary Theory and Age-Associated Diseases 49 VI. Analysis of Two Major Age-Associated Disease Processes 50 VII. Summary and Conclusions 55 ...
Página vi
... Age 125 III. Mitochondrial Dysfunction and Aging 129 IV. Mitochondrial Dysfunction and Age-Associated Disease 134 V. Conclusions 137 References 137 6. P53 and Mouse Aging Models 149 Catherine Gatza, George Hinkal, Lynette Moore, Melissa ...
... Age 125 III. Mitochondrial Dysfunction and Aging 129 IV. Mitochondrial Dysfunction and Age-Associated Disease 134 V. Conclusions 137 References 137 6. P53 and Mouse Aging Models 149 Catherine Gatza, George Hinkal, Lynette Moore, Melissa ...
Página 7
... aging and failure are related to each other in the following way: when the risk of failure outcomes increases with age (“old is not as good as new”), this is aging by definition. Note that according to reliability theory, aging is not ...
... aging and failure are related to each other in the following way: when the risk of failure outcomes increases with age (“old is not as good as new”), this is aging by definition. Note that according to reliability theory, aging is not ...
Página 20
... age in many adult species (Gompertz law)? How should we handle cases when the Gompertzian mortality law is not applicable? 3. Why does the age-related increase in mortality rates vanish at older ages? Why do mortality rates eventually ...
... age in many adult species (Gompertz law)? How should we handle cases when the Gompertzian mortality law is not applicable? 3. Why does the age-related increase in mortality rates vanish at older ages? Why do mortality rates eventually ...
Página 21
... age. Interestingly, recent studies have found that caloric restriction can prevent cell loss (Cohen et al., 2004; McKiernan et al., 2004), which may explain why caloric restriction delays the onset of numerous age-associated diseases ...
... age. Interestingly, recent studies have found that caloric restriction can prevent cell loss (Cohen et al., 2004; McKiernan et al., 2004), which may explain why caloric restriction delays the onset of numerous age-associated diseases ...
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Academy of Sciences activity adult age-associated age-related age-specific alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology extend life span female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature neurons organisms overexpression oxidative stress pathway percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast