Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página v
... Analysis of Two Major Age-Associated Disease Processes VII. Summary and Conclusions 50 55 References 56 3. Dietary Restriction, Hormesis, and Small Molecule Mimetics David A. Sinclair and Konrad T. Howitz I. Introduction 63 II. Key ...
... Analysis of Two Major Age-Associated Disease Processes VII. Summary and Conclusions 50 55 References 56 3. Dietary Restriction, Hormesis, and Small Molecule Mimetics David A. Sinclair and Konrad T. Howitz I. Introduction 63 II. Key ...
Página xvii
... analyses of aging, as does a later chapter recounting how genetics and demography interact in Drosophila studies. Other ... analysis to aging studies. Progress in dissecting the genetics and neuroendocrinology of aging in inverte- brate ...
... analyses of aging, as does a later chapter recounting how genetics and demography interact in Drosophila studies. Other ... analysis to aging studies. Progress in dissecting the genetics and neuroendocrinology of aging in inverte- brate ...
Página 10
... analysis is useful in practice because it allows researchers to determine easily whether particular data follow the Gompertz law or the Weibull law ( or neither ) . Two fundamental differences exist between the Weibull and the Gompertz ...
... analysis is useful in practice because it allows researchers to determine easily whether particular data follow the Gompertz law or the Weibull law ( or neither ) . Two fundamental differences exist between the Weibull and the Gompertz ...
Página 11
... analysis with the Gompertz and the Weibull functions. For the Gompertz function, misspecification of starting age is not as important because the shift in the age scale will still produce the same Gompertz function with the same slope ...
... analysis with the Gompertz and the Weibull functions. For the Gompertz function, misspecification of starting age is not as important because the shift in the age scale will still produce the same Gompertz function with the same slope ...
Página 14
... analysis of complex system failure by focusing on the early failure kinetics of system components. The failure rate of a system connected in series is a sum of failure rates of its components (Barlow et al., 1965): s 1 2 n destroyed ...
... analysis of complex system failure by focusing on the early failure kinetics of system components. The failure rate of a system connected in series is a sum of failure rates of its components (Barlow et al., 1965): s 1 2 n destroyed ...
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Academy of Sciences activity adult age-associated age-related age-specific aging process alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature nematodes neurons organisms overexpression oxidative stress percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast