Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página vi
... Cancer Deborah R. Bell and Gary Van Zant I. Stem Cells 105 II. Stem Cell Aging 108 115 III. Stem Cells and Cancer IV. Conclusions 119 References 119 5. Mitochondria: A Critical Role in Aging 124 105 Tamara R. Golden, Karl Morten ...
... Cancer Deborah R. Bell and Gary Van Zant I. Stem Cells 105 II. Stem Cell Aging 108 115 III. Stem Cells and Cancer IV. Conclusions 119 References 119 5. Mitochondria: A Critical Role in Aging 124 105 Tamara R. Golden, Karl Morten ...
Página 37
... cancer : telomeres , checkpoints , and longevity . Journal of Clinical Investigation , 111 , S9 - S14 . Doblhammer , G. , & Vaupel , J. W. ( 2001 ) . Lifespan depends on month of birth . Proceedings of the National Academy of Sciences ...
... cancer : telomeres , checkpoints , and longevity . Journal of Clinical Investigation , 111 , S9 - S14 . Doblhammer , G. , & Vaupel , J. W. ( 2001 ) . Lifespan depends on month of birth . Proceedings of the National Academy of Sciences ...
Página 40
... cancer : in search of a happy ending . Oncogene , 21 , 503-511 . Klein , J. P. , & Moeschberger , M. L. ( 1997 ) . Survival analysis : techniques for censored and truncated data . New York : Springer- Verlag . Kuh , D. , & Ben - Shlomo ...
... cancer : in search of a happy ending . Oncogene , 21 , 503-511 . Klein , J. P. , & Moeschberger , M. L. ( 1997 ) . Survival analysis : techniques for censored and truncated data . New York : Springer- Verlag . Kuh , D. , & Ben - Shlomo ...
Página 45
... cancers are examples of such diseases. The relationship of cancer to aging will be discussed later in this chapter. Interestingly, in a paper on diseases that cause the death of people 85 years or older, Kohn (1982) divides the diseases ...
... cancers are examples of such diseases. The relationship of cancer to aging will be discussed later in this chapter. Interestingly, in a paper on diseases that cause the death of people 85 years or older, Kohn (1982) divides the diseases ...
Página 46
... cancer , cardiovascular disease , and cataracts . Rattan ( 1991 ) proposed that aging and age - associated disease ... cancer decreased at advanced ages . Smith ( 1996 ) reported that cancer was the cause of 40 percent of deaths that ...
... cancer , cardiovascular disease , and cataracts . Rattan ( 1991 ) proposed that aging and age - associated disease ... cancer decreased at advanced ages . Smith ( 1996 ) reported that cancer was the cause of 40 percent of deaths that ...
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Academy of Sciences activity adult age-associated age-related age-specific aging process alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature nematodes neurons organisms overexpression oxidative stress percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast