Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Elsevier, 2011 M04 28 - 680 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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Página 51
... response recruitment of monocytes and T - lympho- ( Navab et al . , 2004 ) . Bjorkbacka and cytes plus a migration of smooth muscle colleagues ( 2004 ) presented evidence that cells into the lesion as well as their pro- links the pro ...
... response recruitment of monocytes and T - lympho- ( Navab et al . , 2004 ) . Bjorkbacka and cytes plus a migration of smooth muscle colleagues ( 2004 ) presented evidence that cells into the lesion as well as their pro- links the pro ...
Página 52
... response to stim- ulation and that , in addition to playing this role in atherogenesis , there is also evidence that this dysregulation is involved in other age - associated disor- ders . In fact , Chung and colleagues ( 2001 ) believe ...
... response to stim- ulation and that , in addition to playing this role in atherogenesis , there is also evidence that this dysregulation is involved in other age - associated disor- ders . In fact , Chung and colleagues ( 2001 ) believe ...
Página 68
... response in the organ- ism . This stress response then boosts resistance to biological and chemical insults and counteracts the causes of aging . A more detailed description of this theory is presented in a later section . In summary ...
... response in the organ- ism . This stress response then boosts resistance to biological and chemical insults and counteracts the causes of aging . A more detailed description of this theory is presented in a later section . In summary ...
Página 70
... response, causing enhanced cell defenses and metabolic changes, coordinated by the endocrine system Evidence For DR slows development; animals with slower development tend to live longer DR lowers body temperature, some evidence for ...
... response, causing enhanced cell defenses and metabolic changes, coordinated by the endocrine system Evidence For DR slows development; animals with slower development tend to live longer DR lowers body temperature, some evidence for ...
Página 72
... response is that it improves the health and life span of almost every species it has been tested on . It seems unlikely , but possible , that for all these species - yeast , worms , flies , fish , spiders - it is a case of overfeeding ...
... response is that it improves the health and life span of almost every species it has been tested on . It seems unlikely , but possible , that for all these species - yeast , worms , flies , fish , spiders - it is a case of overfeeding ...
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Academy of Sciences activity adult age-associated age-related age-specific aging process alleles analysis animals apoptosis associated biology of aging Caenorhabditis elegans caloric restriction cancer cellular colleagues Curtsinger damage decline decrease disease Drosophila melanogaster effects evolution evolutionary Experimental Gerontology female fibers flies function gene expression gene expression changes genetic genome Gerontology Gompertz growth factor growth hormone Hormesis human IGF-I increased life span insulin signaling insulin-like growth insulin-like growth factor interactions Journal of Gerontology juvenile hormone kinase levels lifespan long-lived longevity male Masoro Mechanisms of Ageing metabolism mice microarray mitochondrial Molecular mortality rates mouse mutations National Academy Nature nematodes neurons organisms overexpression oxidative stress percent phenotypes physiological pleiotropy population Promislow protein QTLs rats receptor regulation reproductive Research response role senescence Sir2 SIRT1 sirtuins skeletal muscle species stem cells stress resistance studies survival Tatar telomere theory tion tissue transcription factor worms yeast