Handbook of the Biology of AgingEdward J. Masoro, Steven N. Austad Academic Press, 2006 - 660 páginas The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions. |
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... V. Empirically Investigating the Similarities and Differences Among Model Organisms 460 VI. Conclusions 462 References 463 400 Section III: Mammalian Models 17. Differential Aging Among Skeletal Muscles viii Contents.
... V. Empirically Investigating the Similarities and Differences Among Model Organisms 460 VI. Conclusions 462 References 463 400 Section III: Mammalian Models 17. Differential Aging Among Skeletal Muscles viii Contents.
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Academy of Sciences activity adult age-related aging altered analysis animals associated Biology body caloric cancer cause cellular changes colleagues compared complex damage death decline decrease disease Drosophila Drosophila melanogaster early effects et al evidence evolution evolutionary example Experimental experiments extend factor failure female fibers Figure flies function gene expression genetic genome Gerontology glucose growth hormone human important increased individuals initial insulin involved Journal lead levels longevity loss major male mechanisms mice mitochondrial Molecular mortality mouse muscle mutations Nature normal observed occur organisms oxidative pathway patterns percent phenotypes physiological population Proceedings production protein QTLs rats recent receptor reduced regulation reported reproductive Research resistance response restriction RNAi role sarcopenia Sciences selection senescence signaling similar span species stem cells stress studies suggest theory tion tissue transcription variation worms young