Self-Assembling Complexes for Gene Delivery: From Laboratory to Clinical TrialAlexander V. Kabanov, Philip L. Felgner, Leonard W. Seymour Wiley, 1998 M05 29 - 442 páginas Recent years have witnessed an explosion of activity in the field of gene therapy. Following advances in our understanding of the molecular basis of disease, hopes are high that the tremendous potential market for drugs employing antisense nucleotides and genes will one day be fulfilled. However, many obstacles remain, not least problems in the technology of gene delivery systems. Much of today's research focuses on non-viral approaches to gene delivery. Of particular importance are supramolecular complexes formed between DNA and various natural and synthetic polymers and lipids, otherwise known as 'self-assembling complexes for gene delivery'. In view of this fact, the editors of this volume have assembled an international team of contributors to present up-to-date reviews of the major chemical, biological and clinical aspects of such gene delivery vectors. Reflecting the diversity of research in this field, this book comprehensively covers: * the principles of self-assembly * natural mechanisms for gene delivery to cells * cationic lipids and liposomes * polyelectrolyte DNA complexes * systemic biodistribution of drug delivery systems * targeting of conjugates for gene delivery * new approaches to gene delivery * clinical evaluation Self-assembling Complexes for Gene Delivery is an essential reference for all professionals with an interest in gene and antisense therapy or novel drug delivery systems, including medicinal and pharmaceutical chemists, clinicians, human geneticists, molecular biologists and pharmacologists. |
Contenido
Polymorphism of lipids nucleic acids and their interactions | 3 |
Structure of polycationDNA complexes and theories of compaction | 27 |
Selfassembly of bacteriophage | 51 |
Derechos de autor | |
Otras 17 secciones no mostradas
Términos y frases comunes
Acad Sci USA adenovirus aggregation antibody antisense bacteriophage binding Biochem Bioconj Chem Biol Chem Biopolymers Birnstiel ML block copolymers Bloomfield capsid cationic lipids cationic liposomes Cell Biol cellular chains charge ratio chloroquine clathrin colloid compact concentration condensed DNA conjugates Cotten cytoplasm delivery systems dendrimers DNA complexes DNA condensation drug electrostatic endocytosis endosomes Felgner Figure gene delivery gene expression gene therapy gene transfer histone Huang Human Gene Ther injection interactions intracellular IPEC Kabanov ligand light scattering liposomes LPDII macromolecules mechanism mediated membrane Mol Biol molecular weight molecules Natl Acad Sci nonviral nuclear nucleic acid nucleus observed oligonucleotides particles peptides PEVP phage phase plasmid plasmid DNA polycation polyelectrolyte polyion polylysine polymerization Proc Natl Acad receptor receptor-mediated Self-assembling serum solution spermidine stearyl-pLL structure studies synthetic Szoka targeting terplex system toroids transfection transfection activity transfection efficiency uptake vectors vesicles viral Virol virus viruses vitro Wagner
Referencias a este libro
Gene Therapy: Therapeutic Mechanisms And Strategies Nancy Smyth Templeton,D. D. Lasic Vista de fragmentos - 2000 |