Aging at the Molecular LevelThomas von Zglinicki Springer Science & Business Media, 2013 M06 29 - 248 páginas During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry. |
Contenido
Oxidative DNA damage and repair implications for aging | 11 |
Oxidative damage to proteins | 26 |
Ageing rate mitochondrial free radical production | 47 |
Genomic instability in human premature aging | 65 |
Oxidative damage somatic mutations and cellular aging | 78 |
Biological clocks in the aging cell | 107 |
Telomeric damage in aging | 121 |
Probing the in vivo relevance of oxidative stress in aging | 130 |
Nonoxidative modification of DNA and proteins | 145 |
Transcriptional and translational dysregulation during aging | 179 |
Metabolic regulation of gene silencing and life span | 192 |
The proteasome in aging | 213 |
Aging and lysosomal degradation of cellular constituents | 232 |
| 243 | |
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20S proteasome Acad Sci USA accumulation acetylation acid residues age-related amino acid animals antioxidant apoptosis Biol Chem caloric restriction carbonyl carnosine cellular senescence cerevisiae cross-linked culture deacetylase deamidation decrease degradation disease DNA glycosylase DNA repair Drosophila enzymes Exp Gerontol fatty acid fibroblasts Free Radic Biol free radical gene expression Genet genome glutathione glycation histone human fibroblasts increased induced inhibition levels lifespan lipid peroxidation lipofuscin liver longevity lysine lysosomal mammalian Mech Ageing Dev mechanism membrane metabolic methylation mice mitochondrial DNA MLSP modification molecular molecules mouse mtDNA mutations Natl Acad Sci nicotinamide normal overexpression oxidative damage oxidative stress oxidized proteins pathway peptides phenotype polymerase Proc Natl Acad production proteasome proteasome activity protein oxidation protein synthesis reaction regulation replicative senescence ribosomal role Sir2 Sohal span structure studies subunits superoxide dismutase telomerase telomere telomere shortening theory of aging tissues transcription transgenic vitro vivo Werner syndrome yeast Zglinicki