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I am constantly referring this book to people to read, since even though it was published nearly a decade ago, it contains the very basic underpinnings of the field of comparative/functional genomics, by two scientists whose work was very influential in creating that field. Perhaps what impressed me most (and the reason I keep referring it to others) was that it contains the most accessible description of sequence homology searches that I have ever read, giving practical advice on how to get the most out of BLAST and related homology search tools. In fact, I was so impressed by this book and the work done in Koonin's group at NCBI that I even joined his lab to learn more (and therefore my review should be considered biased, although since I read it first before joining, perhaps not completely so).