Science In Medicine: The JCI Textbook Of Molecular MedicineJones & Bartlett Learning, 2007 M10 31 - 1157 páginas Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers. |
Contenido
PART | 11 |
Pharmacological manipulation of cell death | 18 |
Reawakening the cellular death program in neoplasia through the therapeutic | 34 |
pharmacological manipulation of cell death | 47 |
an innocent convict? | 62 |
ONCOLOGY | 81 |
Integrins in invasive growth | 87 |
Do tumorsuppressive mechanisms contribute to organism aging by inducing | 102 |
Regulation and mechanisms of macrophage cholesterol efflux | 596 |
Isoprenoids as mediators of the biological effects of statins | 615 |
Mechanisms of sudden cardiac death | 623 |
Muscle channelopathies and critical points in functional and genetic studies | 649 |
Cardiac and skeletal muscle disorders caused by mutations in the intracellular | 669 |
HEMATOLOGY | 683 |
Thrombus formation in vivo | 700 |
The biogenesis of platelets from megakaryocyte proplatelets | 716 |
Bmi1 stem cells and senescence regulation | 120 |
Melanoma genetics and the development of rational therapeutics | 144 |
888 | 169 |
progress reveals new complexities | 171 |
lessons from cytokine | 184 |
CD4+ Tregs and immune control | 203 |
Tregs and transplantation tolerance | 221 |
898 | 225 |
New insights into atopic dermatitis | 234 |
Exploiting dendritic cells to improve vaccine efficacy | 253 |
Grampositive bacteria in health and disease | 269 |
Development of an improved vaccine for anthrax | 282 |
The emergence of Lyme disease | 297 |
Bacterial communication | 307 |
Quorum sensing and biofilm formation in Streptococcal infections | 323 |
Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target | 337 |
Parasitic infections | 352 |
new opportunities for treatment and prevention | 366 |
defining protective versus pathologic immunity | 380 |
Entry of parainfluenza virus into cells as a target for interrupting childhood | 405 |
Liveattenuated virus vaccines for respiratory syncytial and parainfluenza | 420 |
RESPIRATORY SYSTEM | 439 |
JAKSTAT signaling in asthma | 455 |
CARDIOVASCULAR SYSTEM | 475 |
Genetic causes of human heart failure | 494 |
chemical screens | 514 |
Death begets failure in the heart | 532 |
Vascular diseases | 568 |
Malformation syndromes due to inborn errors of cholesterol synthesis | 581 |
Structure and function of the platelet integrin alьẞ3 | 730 |
policies practices and ethical issues related | 745 |
Molecular mediators of hepatic steatosis and liver injury | 764 |
activators of the complete program of cholesterol and fatty acid | 780 |
focus on insulin secretion | 797 |
Regeneration of the pancreatic ẞ cell | 816 |
How does blood glucose control with insulin save lives in intensive care? | 831 |
Inflammation stress and diabetes | 852 |
Robert W Schrier Wei Wang Brian Poole and Amit Mitra | 888 |
PART 12 BONE AND MINERAL METABOLISM | 917 |
an inflammatory tale | 935 |
Neale Weitzmann and Roberto Pacifici | 944 |
NEUROLOGIC DISORDERS | 954 |
Jeffrey A Klein and Susan L Ackerman | 963 |
Can the amyloid cascade be halted? | 989 |
molecules to medicine | 996 |
Huntingtin in health and disease | 1007 |
Multiple sclerosis | 1019 |
Progress and problems in the biology diagnostics and therapeutics of prion | 1027 |
The genetic epidemiology of neurodegenerative disease | 1035 |
Sodium channel mutations in epilepsy and other neurological disorders | 1044 |
Finding schizophrenia genes | 1052 |
insights from imaging studies | 1061 |
GENETICS AND DISEASE | 1069 |
Linkage disequilibrium maps and association mapping | 1080 |
translating genomic science into clinical practice | 1086 |
Payment of clinical research subjects | 1098 |
Embryonic death and the creation of human embryonic stem cells | 1105 |
Términos y frases comunes
Acad activation acute aeruginosa antiapoptotic antibodies antigen apoptosis apoptotic aureus autoimmune autophagy bacterial binding biofilm cancer cells caspase CD4+ T cells CD8+ Cell Biol cell death cellular Chem chronic Clin clinical complex cytokines disease domain drug effects encoding enhanced expression factor Foxp3 function gene genetic growth Helicobacter pylori HN protein host human IFN-y immune responses immunogenicity Immunol increased induced infection inhibition inhibitors integrin interaction kinase ligand lymphocytes lymphoma mechanisms mediated melanoma membrane mice mitochondrial molecular molecules MOMP mouse mutations Natl Oncogene overexpression pathogenic pathway patients peptide phenotype phosphorylation pituitary potential Proc psoriasis pylori quorum sensing receptor recombinant regulation regulatory T cells resistance role senescence sepsis signaling skin specific stem cells studies subsets suppression suppressor survival syndrome target telomerase telomere therapeutic therapy tion tissue transcription treatment Tregs tumor tumor cells vaccine viral virus vitro vivo XIAP