Science In Medicine: The JCI Textbook Of Molecular Medicine

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Jones & Bartlett Learning, 2007 M10 31 - 1157 páginas
Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers.
 

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Contenido

PART
11
Pharmacological manipulation of cell death
18
Reawakening the cellular death program in neoplasia through the therapeutic
34
pharmacological manipulation of cell death
47
an innocent convict?
62
ONCOLOGY
81
Integrins in invasive growth
87
Do tumorsuppressive mechanisms contribute to organism aging by inducing
102
Regulation and mechanisms of macrophage cholesterol efflux
596
Isoprenoids as mediators of the biological effects of statins
615
Mechanisms of sudden cardiac death
623
Muscle channelopathies and critical points in functional and genetic studies
649
Cardiac and skeletal muscle disorders caused by mutations in the intracellular
669
HEMATOLOGY
683
Thrombus formation in vivo
700
The biogenesis of platelets from megakaryocyte proplatelets
716

Bmi1 stem cells and senescence regulation
120
Melanoma genetics and the development of rational therapeutics
144
888
169
progress reveals new complexities
171
lessons from cytokine
184
CD4+ Tregs and immune control
203
Tregs and transplantation tolerance
221
898
225
New insights into atopic dermatitis
234
Exploiting dendritic cells to improve vaccine efficacy
253
Grampositive bacteria in health and disease
269
Development of an improved vaccine for anthrax
282
The emergence of Lyme disease
297
Bacterial communication
307
Quorum sensing and biofilm formation in Streptococcal infections
323
Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target
337
Parasitic infections
352
new opportunities for treatment and prevention
366
defining protective versus pathologic immunity
380
Entry of parainfluenza virus into cells as a target for interrupting childhood
405
Liveattenuated virus vaccines for respiratory syncytial and parainfluenza
420
RESPIRATORY SYSTEM
439
JAKSTAT signaling in asthma
455
CARDIOVASCULAR SYSTEM
475
Genetic causes of human heart failure
494
chemical screens
514
Death begets failure in the heart
532
Vascular diseases
568
Malformation syndromes due to inborn errors of cholesterol synthesis
581
Structure and function of the platelet integrin alьẞ3
730
policies practices and ethical issues related
745
Molecular mediators of hepatic steatosis and liver injury
764
activators of the complete program of cholesterol and fatty acid
780
focus on insulin secretion
797
Regeneration of the pancreatic ẞ cell
816
How does blood glucose control with insulin save lives in intensive care?
831
Inflammation stress and diabetes
852
Robert W Schrier Wei Wang Brian Poole and Amit Mitra
888
PART 12 BONE AND MINERAL METABOLISM
917
an inflammatory tale
935
Neale Weitzmann and Roberto Pacifici
944
NEUROLOGIC DISORDERS
954
Jeffrey A Klein and Susan L Ackerman
963
Can the amyloid cascade be halted?
989
molecules to medicine
996
Huntingtin in health and disease
1007
Multiple sclerosis
1019
Progress and problems in the biology diagnostics and therapeutics of prion
1027
The genetic epidemiology of neurodegenerative disease
1035
Sodium channel mutations in epilepsy and other neurological disorders
1044
Finding schizophrenia genes
1052
insights from imaging studies
1061
GENETICS AND DISEASE
1069
Linkage disequilibrium maps and association mapping
1080
translating genomic science into clinical practice
1086
Payment of clinical research subjects
1098
Embryonic death and the creation of human embryonic stem cells
1105
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