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The news is that a symmetrical pair of processes, the second law of thermodynamics and derived meaning, are enough to generate reality. This bootstraps the existence of information which outweighs matter and energy, while the universe moves to maximize entropy and disorder, and we embody natural laws. That provides a source of ideas which the scientific method, or its analogs in other disciplines, turns into rules of nature. Quantum physics reveals meaning and the other side of the story of creation. The author synthesizes a coherent framework for quantum information science. Landauer’s principle that information is physical, where entropy is proportional to surface area, inspires a combination with Shannon’s information as inverse probability, Boltzmann’s constant, and qubits, to yield randomness at small scales and determinism at large. Twelve chapters explore perspectives of biology, thermodynamics, economics, computer science, sociology, philosophy and quantum physics. Each chapter mixes explanation, observation, anecdotes and humor, and is followed by a summary of the key points. Applications include cryptography, teleportation, climate, diet, segregation and gambling. Literature sources include Popper, Smolin, and Singh. Compare publications by Seth Lloyd, George Johnson, Michael Nielsen and Isaac Chuang, Amir Aczel or Raymond Kurzweil. The challenge is to integrate gravity to quantum physics.