The Vaccine BookBarry R. Bloom, Paul-Henri Lambert Academic Press, 2003 - 436 páginas A definitive and readable reference guide to the world of vaccines! The Vaccine Book provides concrete information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. The Vaccine Book is designed to increase the understanding of vaccines for students, researchers, public health officials, and all others working to address such challenges. Topics unique to this book: * Ethics * Economics * Diseases that could be prevented * Clinical trial designs * Ideas about the future of vaccines * Challenges facing research scientists in the vaccine area * Burden of vaccine-preventable illness and the impact of vaccines * Scientific obstacles to be overcome by existing and new vaccines * Basic mechanisms of host immunity and pathogen interaction with host tissues * New approaches to future vaccines against challenging diseases * Real and perceived safety issues which dominate vaccine development and vaccination policies * Microbial pathogenesis as a basis for vaccine design * Planning vaccine trials * Introducing new vaccines into the healthcare system * Future challenges for vaccines and immunizations |
Dentro del libro
Resultados 1-5 de 48
Página viii
... Epidemiology ELIZABETH MILLER I. Introduction 37 II . Potential Epidemiological Outcomes 38 A. Containment 38 B. Elimination 38 C. Eradication 38 III . Surveillance of Immunization Programs 39 IV . Immunization Policy Determination V ...
... Epidemiology ELIZABETH MILLER I. Introduction 37 II . Potential Epidemiological Outcomes 38 A. Containment 38 B. Elimination 38 C. Eradication 38 III . Surveillance of Immunization Programs 39 IV . Immunization Policy Determination V ...
Página xiv
... Epidemiology 190 III . Polio Vaccines 191 IV . Polio and Its Global Eradication A. History and Strategy 192 B. Progress to Date References 196 C Rubella 193 JENNIFER M. BEST AND SIOBHAN O'SHEA I. Description of the Disease 197 192 A ...
... Epidemiology 190 III . Polio Vaccines 191 IV . Polio and Its Global Eradication A. History and Strategy 192 B. Progress to Date References 196 C Rubella 193 JENNIFER M. BEST AND SIOBHAN O'SHEA I. Description of the Disease 197 192 A ...
Página xv
... Epidemiology and Disease Burden 226 IV . Virology 227 V. Rotavirus Strain Prevalence 229 VI . Rationale for Immunization against Rotavirus 230 VII . Rotavirus Vaccines 230 A. Nonhuman Strain Vaccines : " Jennerian " Approach 230 1 ...
... Epidemiology and Disease Burden 226 IV . Virology 227 V. Rotavirus Strain Prevalence 229 VI . Rationale for Immunization against Rotavirus 230 VII . Rotavirus Vaccines 230 A. Nonhuman Strain Vaccines : " Jennerian " Approach 230 1 ...
Página xvi
... Epidemiology 258 A. Disease 258 B. Nasopharyngeal Colonization 261 IV . Pathogenesis 262 V. Immunology 263 VI . Pneumococcal Conjugate Vaccine Immunology 264 A. Is There a Response in Children in Whom There Is No Response to ...
... Epidemiology 258 A. Disease 258 B. Nasopharyngeal Colonization 261 IV . Pathogenesis 262 V. Immunology 263 VI . Pneumococcal Conjugate Vaccine Immunology 264 A. Is There a Response in Children in Whom There Is No Response to ...
Página xvii
... Epidemiology of the Diseases A. Cutaneous Warts 312 B. Laryngeal Papillomas 312 312 C. Genital Warts 313 D. Cervical Neoplasias 313 III . Mechanism of Protection and Surrogate End Points 314 A. Immune Biology of Papillomavirus ...
... Epidemiology of the Diseases A. Cutaneous Warts 312 B. Laryngeal Papillomas 312 312 C. Genital Warts 313 D. Cervical Neoplasias 313 III . Mechanism of Protection and Surrogate End Points 314 A. Immune Biology of Papillomavirus ...
Contenido
CHAPTER 1 GLOBAL BURDEN OF DISEASE | 1 |
CHAPTER 2 IMMUNOLOGY | 51 |
CHAPTER 3 TRIAL DESIGN FOR VACCINES | 85 |
CHAPTER 4 ETHICS AND VACCINES | 119 |
CHAPTER 5 UNDERSTANDING MICROBIAL PATHOGENESIS AS A BASIS FOR VACCINE DESIGN | 129 |
Selected Cases | 179 |
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activation adjuvant adults adverse events agents antibody antibody responses antigens attenuated bacterial cancer CD4+ T cells CD8+ cellular challenge clinical trials cost cost-effectiveness coverage cytokines cytotoxic developing countries DNA vaccines doses effective effector efficacy Epidemiol epidemiology epitopes eradication evaluation falciparum genes genome global Haemophilus influenzae Helicobacter pylori hepatitis HIV vaccine host cell human IFN-y immune response immunization programs immunogenicity Immunol immunological incidence increase individuals induce infants infectious diseases intussusception major malaria vaccine measles memory meningococcal mice molecules Mycobacterium neonatal occur parasite pathogens Pediatr peptide pertussis vaccines Plasmodium Plasmodium falciparum pneumococcal conjugate vaccine polio poliovirus polysaccharide population potential prevent production protein pylori receptor recombinant risk rotavirus vaccine rubella vaccine serotypes specific strains strategies Streptococcus pneumoniae studies surveillance T-cell T-cell responses target infection tetanus tion transmission tuberculosis vaccine development viral virus viruses World Health Organization