The Vaccine BookBarry R. Bloom, Paul-Henri Lambert Academic Press, 2003 - 436 páginas A definitive and readable reference guide to the world of vaccines! The Vaccine Book provides concrete information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. The Vaccine Book is designed to increase the understanding of vaccines for students, researchers, public health officials, and all others working to address such challenges. Topics unique to this book: * Ethics * Economics * Diseases that could be prevented * Clinical trial designs * Ideas about the future of vaccines * Challenges facing research scientists in the vaccine area * Burden of vaccine-preventable illness and the impact of vaccines * Scientific obstacles to be overcome by existing and new vaccines * Basic mechanisms of host immunity and pathogen interaction with host tissues * New approaches to future vaccines against challenging diseases * Real and perceived safety issues which dominate vaccine development and vaccination policies * Microbial pathogenesis as a basis for vaccine design * Planning vaccine trials * Introducing new vaccines into the healthcare system * Future challenges for vaccines and immunizations |
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... GLOBAL BURDEN OF DISEASE A The Burden of Vaccine - Preventable Diseases MAUREEN BIRMINGHAM AND CLAUDIA STEIN I. Introduction . The Global Burden of Infectious and Parasitic Diseases II . Brief Historical Perspective of Vaccinology 3 III ...
... GLOBAL BURDEN OF DISEASE A The Burden of Vaccine - Preventable Diseases MAUREEN BIRMINGHAM AND CLAUDIA STEIN I. Introduction . The Global Burden of Infectious and Parasitic Diseases II . Brief Historical Perspective of Vaccinology 3 III ...
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... Global Eradication A. History and Strategy 192 B. Progress to Date References 196 C Rubella 193 JENNIFER M. BEST AND SIOBHAN O'SHEA I. Description of the Disease 197 192 A. Postnatally Acquired Rubella 197 B. Risk of Rubella in ...
... Global Eradication A. History and Strategy 192 B. Progress to Date References 196 C Rubella 193 JENNIFER M. BEST AND SIOBHAN O'SHEA I. Description of the Disease 197 192 A. Postnatally Acquired Rubella 197 B. Risk of Rubella in ...
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Contenido
CHAPTER 1 GLOBAL BURDEN OF DISEASE | 1 |
CHAPTER 2 IMMUNOLOGY | 51 |
CHAPTER 3 TRIAL DESIGN FOR VACCINES | 85 |
CHAPTER 4 ETHICS AND VACCINES | 119 |
CHAPTER 5 UNDERSTANDING MICROBIAL PATHOGENESIS AS A BASIS FOR VACCINE DESIGN | 129 |
Selected Cases | 179 |
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activation adjuvant adults adverse events agents antibody antibody responses antigens attenuated bacterial cancer CD4+ T cells CD8+ cellular challenge clinical trials cost cost-effectiveness coverage cytokines cytotoxic developing countries DNA vaccines doses effective effector efficacy Epidemiol epidemiology epitopes eradication evaluation falciparum genes genome global Haemophilus influenzae Helicobacter pylori hepatitis HIV vaccine host cell human IFN-y immune response immunization programs immunogenicity Immunol immunological incidence increase individuals induce infants infectious diseases intussusception major malaria vaccine measles memory meningococcal mice molecules Mycobacterium neonatal occur parasite pathogens Pediatr peptide pertussis vaccines Plasmodium Plasmodium falciparum pneumococcal conjugate vaccine polio poliovirus polysaccharide population potential prevent production protein pylori receptor recombinant risk rotavirus vaccine rubella vaccine serotypes specific strains strategies Streptococcus pneumoniae studies surveillance T-cell T-cell responses target infection tetanus tion transmission tuberculosis vaccine development viral virus viruses World Health Organization