Handbook of Drug ScreeningRamakrishna Seethala, Prabhavathi Fernandes CRC Press, 2001 M07 24 - 520 páginas A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies. |
Contenido
1 Moving Into the Third Millennium After a Century of Screening | 1 |
2 Basic Considerations in Designing HighThroughput Screening Assays | 5 |
3 Screening Platforms | 31 |
4 Homogeneous Assays for HighThroughput and UltrahighThroughput Screening | 69 |
5 MicrobeBased Screening Systems | 129 |
6 Molecular Genetic Screen Design for Agricultural and Pharmaceutical Product Discovery | 153 |
7 Receptor Screens for Small Molecule Agonist and Antagonist Discovery | 189 |
8 Functional Assay Screens | 265 |
13 HigherThroughput Screening Assays With Human Hepatocytes for HepatotoxicityMetabolic Stabilityand Drug Drug Interaction Potential | 383 |
14 HighThroughput Screening for MetabolismBased Drug Drug Interactions | 403 |
15 The ATCG of Drug Discovery | 415 |
16 GenomicsFunctional Proteomics for Identi cation of New Targets | 433 |
17 Bioinformatics | 447 |
18 The Evolution of Laboratory Automation | 477 |
19 Robotics and Automation | 493 |
20 Assay Miniaturization | 525 |
9 Enzyme Screens | 283 |
10 Screening Strategies for Ion Channel Targets | 313 |
11 HighThroughput Screening Assays for Detection of Transcription | 335 |
12 Screening of Combinatorial Biology Libraries for Natural Products Discovery | 357 |
21 Screening in the NanoWorld | 563 |
| 583 | |
Otras ediciones - Ver todas
Handbook of Drug Screening Ramakrishna Seethala,Prabhavathi Fernandes Sin vista previa disponible - 2001 |
Términos y frases comunes
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