Signal Transduction in Lung CellsJerome Brody CRC Press, 30 mar 1993 - 704 páginas This reference offers detailed discussions of the basic aspects of signal transduction, and examines their applications in lung cell biology. Providing an overview of current research directions, Signal Transduction in Lung Cells covers: the structure and function of receptors; the structure and regulation of G proteins; second messenger systems including kinases and phosphatases; airway and alveolar cells; smooth muscle cells; inflammatory and immune cells; muscle tone, ion channels, growth factors and cytokines.;With over 1900 literature citations and figures, Signal Transduction in Lung Cells is intended as a resource for pulmonologists, physiologists, molecular and cell biologists, pharmacologists, and graduate and medical school students in these disciplines. |
Índice
Molecular Diversity and Functional Correlates in Transmembrane | 1 |
Diversity of Effector Systems | 7 |
Activities of G Proteins | 13 |
Analysis from | 23 |
IV | 43 |
G Proteins in Pulmonary and Cardiovascular Signal | 49 |
Is the NaKATPase One More Effector System Regulated | 69 |
Small GTPases | 81 |
Protein Kinase Substrate Recognition Motifs | 247 |
Protein Phosphatase Structure and Function | 248 |
Protein Phosphorylation and Dephosphorylation Cascades | 251 |
Direct Phosphorylation and Alveolar Epithelial Cell Function | 253 |
Growth Factors and Pulmonary Epithelia | 263 |
Expression and Regulation of Chemotactic Cytokine Genes | 293 |
Signal Transduction Mechanisms and the Expression | 304 |
Mechanical Strain on Cells Can Stimular Mucin Release | 310 |
Rab Proteins | 93 |
Phosphoinositides and Intracellular Calcium | 111 |
Phospholipase C and Receptor Activation | 121 |
ProteinTyrosine Kinases | 147 |
A Multigene Family of Diverse | 181 |
Extracellular ATP and Adenosine as Agonists for ReceptorMediated Signaling | 199 |
Overview of Purinergic Signal Transduction | 200 |
General Overview of ReceptorMediated Signal Transduction | 207 |
Mechanisms Underlying Signal Transduction by P₁Purinergic Receptors | 209 |
P₂Purinergic Receptors | 212 |
Structural Characterization of Receptors for ATP and Adenosine | 215 |
Purinergic Signal Transduction in the Lung | 217 |
References | 219 |
Part Two EPITHELIAL CELLS | 223 |
Epithelial Cell Na+ and Cl Channels | 225 |
Biochemistry of Epithelial Na and C1 Channels | 226 |
AmilorideSensitive Na+ Transport and Its Regulation in Mammalian Alveolar Epithelia | 231 |
AmilorideBinding Proteins in ATII Cells | 238 |
Summary and Perspectus | 239 |
References | 240 |
Protein Phosphorylation and Dephosphorylation Systems in Alveolar Epithelial Cells | 245 |
Protein Kinase Structure and Function | 246 |
Dysregulation of Cellular Genes by Latent Viral Genes | 323 |
Role of Calcium in the Regulation of Smooth Muscle Tone | 335 |
Role of Myosin Phosphorylation in Smooth Muscle | 351 |
Myosin Phosphorylation and Macrophage Motility | 357 |
Growth Factors and Signal Transduction in Smooth | 369 |
Ionic Currents in the Membranes of Cultured Endothelial Cells | 391 |
11 | 394 |
ReceptorDependent Regulation of Ca2+ and Phospholipase C | 415 |
Fluctuations of Free Cytoplasmic Calcium and Magnesium | 421 |
Secretion Profiles of Vasoactive AmineInduced Leukocyte | 435 |
HighAltitude Pulmonary Hypertension and Signal Transduction | 459 |
Effect of Hypoxia on Ca2+ Channels and Intracellular | 469 |
Role of Adrenoceptors in the Genesis of HighAltitude | 476 |
Alveolar Macrophage GrowthFactor Signaling Systems | 483 |
Role of the GTPase Superfamily in TLymphocyte Signal | 521 |
Conclusion | 531 |
Mechanisms of Mast Cell Signaling | 541 |
BetaAdrenergic Receptors on Alveolar Macrophages | 555 |
Summary | 571 |
| 577 | |
| 627 | |
Términos y frases comunes
Acad Sci USA adenylate adenylyl cyclase ADP-ribosylation agonist alpha subunits alveolar macrophages amiloride amino acid antibodies antigen artery ATII cells binding Biochem Biol Chem bovine calcium catalytic cell line cell types cellular channels chemotactic cloning contractile cultured cytokine cytoplasmic cytosolic domain effect effector EGF receptor EGF-URO endothelial cells enzyme epithelial cells epithelium expression fibroblasts function G proteins gene product growth factor GTP-binding proteins GTPase histamine hormones human increase induced inhibition inhibitory inositol insulin interaction interleukin intracellular kinase activity levels ligand lung lymphocytes macrophages mammalian mast cells mechanism mediated molecular molecules mRNA mucin release myosin Natl Acad Sci neutrophil oncogene pathways PDGF pertussis toxin phosphatase phospholipase phosphorylation Physiol plasma membrane Proc Natl Acad protein kinase protein-tyrosine pulmonary regulation regulatory response role secretion sequence signal transduction smooth muscle specific stimulation studies substrate synthesis T-cell TGFß tion tissue transmembrane type II cells tyrosine kinase vascular
Referencias a este libro
Inhalation Aerosols: Physical and Biological Basis for Therapy Anthony J. Hickey Vista previa restringida - 1996 |