Handbook of Stem Cells

Portada
Anthony Atala, Robert Lanza
Academic Press, 2012 M12 31 - 1074 páginas

New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system.

  • Provides comprehensive coverage on this highly topical subject
  • Contains contributions by the foremost authorities and premiere names in the field of stem cell research
  • Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format
 

Contenido

Chapter 40 Stem Cells Derived from Amniotic Fluid
463
Chapter 41 Update on Stem and Progenitor Cells Isolated from Cord Blood
477
Chapter 42 Stem Cells in Extraembryonic Lineages
481
Chapter 43 Mesenchymal Stem Cells in Regenerative Medicine
493
Chapter 44 Multipotent Adult Progenitor Cells
503
Chapter 45 Mesenchymal Stem Cells
513
Chapter 46 Stem Cells Derived from Fat an Update
529
Chapter 47 Ontogeny of the Hematopoietic System
533

Chapter 9 Cell Cycle Regulators in Stem Cells
77
Chapter 10 Cell Fusion and the Differentiated State
89
Chapter 11 How Cells Change Their Phenotype
95
Chapter 12 Somatic Cloning and Epigenetic Reprogramming in Mammals
101
Chapter 13 Engineered Proteins for Controlling Gene Expression
125
Chapter 14 Differentiation in Early Development
139
Chapter 15 Developmental Mechanisms of Regeneration
155
Chapter 16 Primordial Germ Cells in Mouse and Human
179
Chapter 17 CellECM Interactions in Repair and Regeneration
191
Chapter 18 Induced Pluripotent Stem Cells
227
Chapter 19 FeederFree and Defined Culture Conditions for hESC Growth
237
Chapter 20 Isolation and Maintenance of Murine Embryonic Stem Cells
249
Chapter 21 Isolation and Maintenance of Primate ES Cells
255
Chapter 22 Embryonic Stem Cells Derivation and Properties
275
Chapter 23 Approaches for Derivation and Maintenance of Human ES Cells Detailed Procedures and Alternatives
287
Chapter 24 Alternate Sources of Human Embryonic Stem Cells
303
Chapter 25 Genetic Approaches in Human Embryonic Stem Cells and their Derivatives Prospects for Regenerative Medicine
311
Chapter 26 Genetic Manipulation of Human Embryonic Stem Cells
327
Chapter 27 Homologous Recombination in Human Embryonic Stem Cells
339
Chapter 28 Derivation and Differentiation of Human Embryonic Germ Cells
347
Chapter 29 Growth Factors and the SerumFree Culture of Human Pluripotent Stem Cells
357
Chapter 30 FeederFree Culture
365
Chapter 31 Surface Antigen Markers
375
Chapter 32 Lineage Marking
383
Chapter 33 Genomic Reprogramming
393
Chapter 34 Microarray Analysis of Stem Cells and Differentiation
399
Chapter 35 Potential of ES Cell Differentiation Culture for Vascular Biology
409
Chapter 36 Use of Embryonic Stem Cells to Treat Heart Disease
415
Chapter 37 Embryonic Stem Cells in Tissue Engineering
427
Chapter 38 Zebrafish and Stem Cell Research
439
Front Cover
451
Handbook of Stem Cells Volume 2 Adult and Fetal Stem Cells
iii
Copyright
iv
Dedication
v
Contents
vii
Foreword
xi
Preface
xiii
Contributors
xv
Chapter 39 The Development of Epithelial Stem Cell Concepts
451
Chapter 48 Hematopoietic Stem Cells
553
Chapter 49 Cell Therapy for Blood Substitutes
559
Chapter 50 Peripheral Blood Stem Cells
573
Chapter 51 Human Vascular Progenitor Cells
587
Chapter 52 Stem Cells and the Regenerating Heart
595
Chapter 53 Cardiac Stem Cells Biology and Therapeutic Applications
603
Chapter 54 Stem Cells and Heart Disease
621
Chapter 55 Skeletal Muscle Stem Cells
631
Chapter 56 Stem Cells for the Treatment of Muscular Dystrophy
641
Chapter 57 Myoblast Transplantation in Skeletal Muscles
653
Chapter 58 Neurogenesis in the Vertebrate Embryo
665
Chapter 59 The Nervous System
681
Chapter 60 Stem Cells in the Adult Brain
699
Chapter 61 Neural Stem Cells Therapeutic Applications in Neurodegenerative Diseases
707
Chapter 62 Spinal Cord Injury
723
Chapter 63 Sensory Epithelium of the Eye and Ear
739
Chapter 64 Epithelial Skin Stem Cells
753
Chapter 65 Regeneration of Epidermis from Adult Human Keratinocyte Stem Cells
767
Chapter 66 Burns and Skin Ulcers
781
Chapter 67 Stem Cells in the Gastrointestinal Tract
789
Chapter 68 Pancreatic Stem Cells
819
Chapter 69 Adult Progenitor Cells as a Potential Treatment for Diabetes
827
Chapter 70 Islet Cell Therapy and Pancreatic Stem Cells
835
Chapter 71 Cell Therapy of Liver Disease From Hepatocytes to Stem Cells
855
Chapter 72 Adult Liver Stem Cells
873
Chapter 73 Cell Lineages and Stem Cells in the Embryonic Kidney
889
Chapter 74 Orthopaedic Applications of Stem Cells
901
Chapter 75 Somatic Cells Growth and Expansion Potential of T Lymphocytes
915
Chapter 76 Designing Tunable Artificial Matrices for Stem Cell Culture
927
Chapter 77 Stem Cell Gene Therapy
937
Chapter 78 Histogenesis in ThreeDimensional Scaffolds
951
Chapter 79 Stem Cells in Tissue Engineering
965
Chapter 80 Ethical Considerations
973
Chapter 81 Stem Cell Research Religious Considerations
981
Chapter 82 US Stem Cell Research Policy
991
Chapter 83 Overview of the FDA Regulatory Process
1001
Chapter 84 Its Not About Curiosity Its About Cures
1021
Index
1027
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Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World, and Prospect magazine named him one of the Top 50 “World Thinkers. He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

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